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also showed significant increases in serum concentrations of asymmetric dimethylarginine (ADMA), enhanced inhibition of NOS, enhanced catabolism of Arg, increased levels of ornithine (Orn) and proline (Pro), and decreased Arg/Orn ratio in patients with asthma and obstructive sleep apnea (OSA)

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Mast cells (MCs) are stimulated and degranulate, releasing histamine, IL-6, IL-8, prostaglandin D2 and tumor necrosis factor-alpha (TNF)- together with IL-23 and IL-31 and other cytokines (48, 49)

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